Tyrosine kinases (TK) are enzymes that bind ATP and catalyse the transfer of γ-phosphate to tyrosine residues on proteins, thereby regulating their activity and function which can be targets for cancer chemotherapy. Pyrrolo[2,3-d]pyrimidines have aroused recent attention from chemical and biological view points since they have useful properties as being the receptor tyrosine kinases inhibitor. 5,6-Diphenyl-7-substituted-7H-pyrrolo[2,3-d]pyrimidin-4-yl-amineswere synthesized and perform in-vitro EGFR tyrosine kinase activity and from above study, (08a, 08b, 08c) gives excellent in-vitro EGFR activity in compare to standard gifitinib.
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